Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis
نویسندگان
چکیده
منابع مشابه
Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles
Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...
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The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier (BBB) regulating its homeostasis. BBB is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted number of macromolecules from the blood to the brain, protecting it from injuries and disea...
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BBB is acting as a highly selective membrane that separates the circulating blood from brain fluid [1]. This barrier is formed by endothelial cells which are connected to each other at “tight” junctions that create a complete seal between them. Consequently, only lipophilic molecules are able to cross the barrier. Hydrophilic substances, in contrast, are unable to cross the lipid walls unless a...
متن کاملsimultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles
objective(s): the aim of this work was to prepare and characterize magnetic nanoparticles (mnps) as theranostic system to act simultaneously as drug carrier and mri contrast agent. chitosan-coated mnps (cmnps) were prepared and loaded with silymarin. silymarin-loaded cmnps were characterized with various techniques and their potential as mri contrast agent was also evaluated. materials and meth...
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One of the limitations in the drug delivery field is the inability to specifically target therapeutic or imaging agents to certain tissues, organs or tumors. Magnetic nanoparticles have emerged as effective drug delivery systems, which can be directed by externally applied magnetic fields and specifically tailoring their functional properties. Unfortunately, available magnetic nanoparticles wit...
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ژورنال
عنوان ژورنال: Nanomedicine
سال: 2016
ISSN: 1743-5889,1748-6963
DOI: 10.2217/nnm.16.15